Arterial Stiffness in Balkan Endemic Nephropathy, an Environmental Form of Aristolochic Acid Nephropathy
نویسندگان
چکیده
منابع مشابه
Endemic (Balkan) nephropathy is aristolochic acid nephropathy.
Endemic nephropathy is a syndrome that comprises two entities: chronic interstitial nephropathy and urothelial cell cancers predominantly of the upper urinary tract. The etiological agent for the disease is aristolochic acid, a compound found in the plants of Aristolochia spp. The development of urothelial cancers is characterized by the formation of aristolactam DNA adducts leading to mutation...
متن کاملAristolochic Acid as a Risk Factor for Balkan Endemic Nephropathy
Division of Molecular Toxicology, German Cancer Research Center, Heidelberg, Germany Section of Molecular Carcinogenesis, Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK Institute of Pathology, University of Ljubljana, Ljubljana, Slovenia Department of Biochemistry, Charles University, Prague, The Czech Republic Ecole Nationale Supérieure Agronomique de Toulouse, Laborat...
متن کاملAristolochic acid: the common culprit of Chinese herbs nephropathy and Balkan endemic nephropathy.
Balkan endemic nephropathy (BEN) is a devastating tubulointerstitial kidney disease affecting men and women living in rural areas of Bosnia–Herzegovina, Bulgaria, Croatia, Romania and Serbia [1]. The disease occurs exclusively in farming villages situated in valleys of the Danube River and its tributaries. Since its first description in 1956, the geographic distribution as well as other epidemi...
متن کاملAristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer.
Balkan endemic nephropathy (BEN) is found in certain rural areas of the Balkans and affects at least 25,000 inhabitants. Of the many hypotheses on BEN, the Aristolochia hypothesis has recently gained ground substantiated by the investigations on aristolochic acid nephropathy (AAN). On both clinical and morphological grounds, AAN is very similar to BEN. That exposure to aristolochic acid (AA) of...
متن کاملThe assessment of arterial stiffness in endemic (Balkan) nephropathy patients undergoing haemodialysis.
Cardiovascular (CV) complications are the most important cause of morbidity and mortality in patients with advanced chronic kidney disease (CKD). Arterial stiffness (AS) has been recognized as a strong and independent predictor for CV events in CKD. Our aim was to assess indices of AS in a group of Endemic (Balkan) Nephropathy (EN) patients undergoing haemodialysis (HD). Hypertenison was not co...
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ژورنال
عنوان ژورنال: Frontiers in Cardiovascular Medicine
سال: 2018
ISSN: 2297-055X
DOI: 10.3389/fcvm.2018.00166